Activin A targets extrasynaptic NMDA receptors to ameliorate neuronal and behavioral deficits in a mouse model of Huntington disease

Cortical-striatal synaptic dysfunction, including enhanced toxic signaling by extrasynaptic N-methyl-d-aspartate receptors (eNMDARs), precedes neurodegeneration in Huntington disease (HD).A previous study showed Activin A, whose transcription is upregulated by calcium influx via synaptic NMDARs, suppresses eNMDAR signaling.Therefore, we examined th

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Mindfulness-based stress reduction training supplemented with physiological signals from smartwatch improves mindfulness and reduces stress, but not anxiety and depression.

IntroductionMindfulness-Based Stress Reduction (MBSR) helps counteract the negative consequences of stress.An essential aspect of mind-body therapies is learning to be mindful of emotional reactions and bodily sensations, a process defined as interoceptive awareness.This awareness can also be enhanced by providing physiological feedback from a smar

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BrdU Pulse Labelling In Vivo to Characterise Cell Proliferation during Regeneration and Repair following Injury to the Airway Wall in Sheep

The response of S-phase cells labelled with bromodeoxyuridine (BrdU) in sheep airways undergoing repair in response to endobronchial brush biopsy was investigated in this study.Separate sites within the airway tree of anaesthetised sheep were biopsied at intervals prior to pulse charger for dell latitude 3520 labelling with BrdU, which was administ

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